Investigating a new antibody therapy for HIV-1 treatment
HIV-1 dynamics and evolution during trispecific broadly neutralizing antibody therapy
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11058477
This study is testing a new type of treatment for HIV-1 that uses a special antibody designed to boost your immune system's ability to fight the virus, and it's for people living with HIV who want to see if this approach can help them better manage their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11058477 on ClinicalTrials.gov |
What this research studies
This research focuses on a novel treatment approach for HIV-1 using a trispecific broadly neutralizing antibody (bnAb) therapy. The therapy aims to enhance the immune response against HIV by combining three different antibody binding sites into one molecule, potentially improving the effectiveness of treatment. Patients will be monitored for safety and how well the therapy works in reducing the virus in their bodies. This approach could lead to longer-lasting effects compared to traditional treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV-1 who have not responded adequately to existing treatments.
Not a fit: Patients who are not infected with HIV-1 or those who have advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a more effective and long-lasting treatment option for individuals living with HIV-1.
How similar studies have performed: Previous research has shown promise in using broadly neutralizing antibodies for HIV treatment, but this specific trispecific approach is novel.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TSIBRIS, ATHE M. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: TSIBRIS, ATHE M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, acquired immunodeficiency syndrome clinical trial group, Acquired Immunodeficiency Syndrome Virus