Investigating a new antibody for diagnosing and treating Alzheimer's disease
Anti-high molecular weight kininogen antibody for Alzheimer's disease diagnosis and therapy
This study is looking at a special protein linked to Alzheimer's disease to see how it affects the condition, and researchers are creating new antibodies that could help identify patients and lead to better treatments, which could ultimately help those living with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10875728 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein involved in Alzheimer's disease (AD) and how it contributes to the disease's progression. Researchers are developing antibodies that target high molecular weight kininogen, which may help identify patients with AD and potentially offer a new therapeutic approach. By studying the interaction between the Aβ peptide and the blood coagulation system, the research aims to uncover new mechanisms of AD pathology. Patients may benefit from improved diagnostic methods and innovative treatment options if the antibodies prove effective.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment options for Alzheimer's disease patients.
How similar studies have performed: While the approach of targeting the contact system in Alzheimer's disease is relatively novel, preliminary evidence suggests that similar strategies have shown promise in other studies.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Norris, Erin H — Rockefeller University
- Study coordinator: Norris, Erin H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.