Investigating a new anti-inflammatory compound derived from tryptophan
Official title: Biochemical and functional characterization of a novel anti-inflammatory biogenic amine
Funded at Weill Medical Coll of Cornell Univ · NIH-10881942 · Data updated 2026-11-12
This study is looking at a new substance called 3HKA, made from tryptophan, to see how it helps control inflammation in the immune system, which could lead to new treatments for autoimmune conditions like psoriasis and lupus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 6, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $719,898 |
| NIH project number | 5R01AI169723-02 |
| Project ID | NIH-10881942 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune diseases such as psoriasis or lupus.
✕Less likely to help
Patients with non-autoimmune inflammatory conditions may not benefit from this research.
What this research studies
This research focuses on a novel biogenic amine called 3HKA, which is produced from the metabolism of tryptophan. The study aims to understand how 3HKA functions in regulating the immune system, particularly its anti-inflammatory effects on immune cells. Researchers will conduct biochemical and biophysical analyses to identify the enzymes involved in 3HKA production and explore its potential therapeutic benefits in conditions like psoriasis and lupus. By examining its effects on inflammation and immune response, this research seeks to uncover new treatment avenues for autoimmune diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for autoimmune diseases by harnessing the anti-inflammatory properties of 3HKA.
How similar studies have gone: Previous research has shown promise in using metabolic pathways for immune regulation, suggesting potential success for this novel approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Santambrogio, Laura — Weill Medical Coll of Cornell Univ
- Study coordinator: Santambrogio, Laura
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.