Investigating a natural compound to target mitochondria in lung cancer
Official title: Targeting phenethyl isothiocyanate to mitochondria in lung carcinogenesis
Funded at Methodist Hospital Research Institute · NIH-11023073 · Data updated 2026-11-12
This study is looking at a natural compound from vegetables like broccoli that might help stop lung cancer by making it work better in the parts of cells that produce energy, and it's for anyone interested in new ways to prevent lung cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Methodist Hospital Research Institute NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | February 2, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $625,471 |
| NIH project number | 5R01CA280746-02 |
| Project ID | NIH-11023073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals at high risk for lung cancer, particularly those with a history of smoking or exposure to carcinogens.
✕Less likely to help
Patients with advanced lung cancer or those who have already undergone extensive treatment may not benefit from this research.
What this research studies
This research focuses on a natural compound called phenethyl isothiocyanate (PEITC), which is found in cruciferous vegetables, and its potential to inhibit lung cancer development. The study aims to enhance the effectiveness of PEITC by targeting it specifically to mitochondria, the energy-producing structures in cells. By understanding how this compound affects cancer cell metabolism and promotes cell death, researchers hope to uncover new strategies for preventing lung cancer. The research will involve laboratory experiments using modified lung cancer cells and animal models to evaluate the compound's effectiveness and mechanisms of action.
Why it matters
Potential benefit: If successful, this research could lead to new preventive treatments for lung cancer that are more effective and targeted.
How similar studies have gone: Previous studies have shown promising results with similar compounds in animal models, suggesting potential for success in this novel approach.
Where this research is happening
-
Methodist Hospital Research Institute
Houston, United States Active
Researchers
- Principal investigator: You, Ming — Methodist Hospital Research Institute
- Study coordinator: You, Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.