Investigating a mucin protein's role in breast cancer spreading to the brain
Targeting MUC5AC mucin in breast cancer brain metastasis
This study is looking at how a specific protein called MUC5AC might help breast cancer spread to the brain, especially in more aggressive cases, to see if it can be used as an early warning sign for patients and to find better ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11011431 on NIH RePORTER |
What this research studies
This research focuses on understanding how the MUC5AC mucin protein contributes to the spread of breast cancer to the brain, particularly in aggressive subtypes. By analyzing tissue samples and patient serum, the study aims to identify MUC5AC as a potential biomarker for early detection of brain metastasis in breast cancer patients. The researchers will also explore the mechanisms by which MUC5AC influences cancer cell behavior, including their ability to migrate and cross the blood-brain barrier. This could lead to new strategies for monitoring and treating breast cancer patients at risk of brain metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are women diagnosed with breast cancer, particularly those with triple receptor-negative or ErbB2+ subtypes.
Not a fit: Patients with breast cancer who do not have a risk of brain metastasis or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of brain metastasis in breast cancer patients, potentially improving treatment outcomes.
How similar studies have performed: Previous research has indicated that targeting specific biomarkers can improve detection and treatment strategies in cancer, suggesting a promising avenue for this approach.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Nasser, Mohd Wasim — University of Nebraska Medical Center
- Study coordinator: Nasser, Mohd Wasim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.