Investigating a mouse model for breast cancer linked to persistent tissue changes
Official title: A Mouse Model of Persistence of Ductal and Alveolar Hyperplasia and Breast Cancer
Funded at Portland VA Medical Center · NIH-11053394 · Data updated 2026-11-12
This study is looking at how certain changes in breast tissue might raise the risk of breast cancer in women, using special mice that mimic postmenopausal conditions to help us understand these changes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006607-01A1 |
| Project ID | NIH-11053394 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women with increased breast density or a family history of breast cancer.
✕Less likely to help
Patients who are not postmenopausal or do not have breast density issues may not benefit from this research.
What this research studies
This research focuses on understanding how certain changes in breast tissue, specifically the persistence of terminal duct lobular units (TDLUs), may increase the risk of breast cancer in women. By using a specially designed mouse model, researchers aim to explore the mechanisms behind these changes and their implications for breast cancer development. The study will involve genetically engineered mice that mimic the conditions seen in postmenopausal women, allowing for a detailed examination of tissue behavior over time. This approach could provide insights into why some women have a higher risk of breast cancer based on their breast density and tissue characteristics.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potentially new strategies for breast cancer prevention and detection.
How similar studies have gone: While similar studies have explored breast tissue changes, this specific mouse model approach is novel and has not been extensively tested before.
Where this research is happening
-
Portland VA Medical Center
Portland, United States Active
Researchers
- Principal investigator: Luoh, Shiuh-Wen — Portland VA Medical Center
- Study coordinator: Luoh, Shiuh-Wen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.