Investigating a metabolite linked to exercise and heart health.
DMGV and the AGXT2 pathway in chronic exercise-induced cardiometabolic adaptations.
This study is looking at how a substance called DMGV changes when you exercise and how that might affect your heart health, with the goal of helping people understand how their unique metabolism can influence their exercise results.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10843865 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific metabolite, Dimethylguanidino valeric acid (DMGV), relates to exercise and cardiovascular health. The project aims to explore how DMGV levels change with aerobic exercise and how these changes affect heart disease risk and metabolic health. By combining laboratory training and mentorship in metabolomics and exercise physiology, the research seeks to identify potential biomarkers that could help tailor exercise programs for better health outcomes. Patients may benefit from insights into how their individual metabolic profiles can influence their response to exercise.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who engage in aerobic exercise and may be at risk for cardiometabolic diseases.
Not a fit: Patients who do not participate in aerobic exercise or have no interest in exercise-based interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized exercise recommendations that improve cardiovascular health and metabolic outcomes for patients.
How similar studies have performed: Previous research has shown promising results in linking metabolic markers to exercise responses, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Robbins, Jeremy — Beth Israel Deaconess Medical Center
- Study coordinator: Robbins, Jeremy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.