Investigating a medication to reduce cocaine cravings
A Human Laboratory Study of Exenatide for Reducing the Reinforcing Effects of Cocaine
This study is looking at whether a medication called exenatide can help people with cocaine use disorder by reducing their cravings and the urge to use cocaine, and it’s designed for individuals who are trying to overcome their addiction.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10841703 on NIH RePORTER |
What this research studies
This research explores the use of exenatide, a medication that stimulates the glucagon-like peptide 1 receptor, to help reduce cravings and the reinforcing effects of cocaine in individuals with cocaine use disorder. The study aims to determine if chronic administration of exenatide can improve treatment outcomes by decreasing drug-seeking behavior and cravings. Participants will be monitored in a controlled environment to assess the medication's effects on their responses to cocaine. The research seeks to build on previous findings and address limitations from earlier studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cocaine use disorder who are seeking treatment.
Not a fit: Patients who do not have a cocaine use disorder or those who are currently using other substances may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new pharmacotherapy option that significantly improves treatment outcomes for individuals struggling with cocaine use disorder.
How similar studies have performed: While there has been limited success with similar approaches, this study aims to address previous limitations and explore the potential of exenatide more thoroughly.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Verrico, Christopher D — Baylor College of Medicine
- Study coordinator: Verrico, Christopher D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.