Investigating a mechanism to reduce chronic pain after surgery
Validating ASCT2 for the Treatment of Chronic Postsurgical Pain
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11078376
This study is looking at how surgery changes the way certain nerve cells work and how that might lead to long-lasting pain afterward, with the hope of finding new ways to help people manage that pain without using opioids.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11078376 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how surgery affects the metabolism of sensory neurons and its role in chronic postsurgical pain. It aims to validate the importance of a specific transporter, ASCT2, in the resolution of this pain. By studying how surgical trauma alters metabolic processes, particularly the balance between pyruvate oxidation and glutamine catabolism, the researchers hope to identify new therapeutic targets. The ultimate goal is to develop strategies that can help alleviate chronic pain without relying on opioids.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone surgery and are experiencing chronic pain as a result.
Not a fit: Patients who have not had surgery or those whose pain is unrelated to surgical procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce chronic pain after surgery, improving recovery and quality of life for patients.
How similar studies have performed: Other research has shown promise in exploring metabolic pathways for pain management, suggesting that this approach could yield significant insights.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELEMEDJIAN, OHANNES KEVORK — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: MELEMEDJIAN, OHANNES KEVORK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.