Investigating a marker for lung function and its link to organ dysfunction in critically ill children
Official title: Alveolar Dead Space and New or Progressive MODS
Funded at Children's Hospital of Los Angeles · NIH-10740810 · Data updated 2026-11-12
This study is looking at how a lung function marker can help doctors spot critically ill children who might be at risk for serious complications, so they can get the right care sooner.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $176,515 |
| NIH project number | 1R03HD110889-01A1 |
| Project ID | NIH-10740810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill children aged 0-21 years who are mechanically ventilated in intensive care units.
✕Less likely to help
Patients who are not critically ill or those who are not mechanically ventilated may not benefit from this research.
What this research studies
This research focuses on understanding how a specific lung function marker, known as alveolar dead space, can indicate the risk of new or worsening multiple organ dysfunction syndrome (NPMODS) in critically ill children. By analyzing routinely collected clinical data from mechanically ventilated patients, the study aims to identify children at higher risk for NPMODS, which is associated with increased mortality. The approach involves measuring alveolar dead space alongside other markers of microvascular dysfunction to improve early detection and management of these patients in intensive care units.
Why it matters
Potential benefit: If successful, this research could lead to improved early identification and treatment strategies for critically ill children at risk of severe organ dysfunction.
How similar studies have gone: Previous research has shown promising results in using similar physiological markers to predict outcomes in critically ill patients, suggesting that this approach may be effective.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Bhalla, Anoopindar — Children's Hospital of Los Angeles
- Study coordinator: Bhalla, Anoopindar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.