Investigating a marker for lung function and its link to organ dysfunction in critically ill children
Alveolar Dead Space and New or Progressive MODS
['FUNDING_R03'] · CHILDREN'S HOSPITAL OF LOS ANGELES · NIH-10740810
This study is looking at how a lung function marker can help doctors spot critically ill children who might be at risk for serious complications, so they can get the right care sooner.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSPITAL OF LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10740810 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific lung function marker, known as alveolar dead space, can indicate the risk of new or worsening multiple organ dysfunction syndrome (NPMODS) in critically ill children. By analyzing routinely collected clinical data from mechanically ventilated patients, the study aims to identify children at higher risk for NPMODS, which is associated with increased mortality. The approach involves measuring alveolar dead space alongside other markers of microvascular dysfunction to improve early detection and management of these patients in intensive care units.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill children aged 0-21 years who are mechanically ventilated in intensive care units.
Not a fit: Patients who are not critically ill or those who are not mechanically ventilated may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early identification and treatment strategies for critically ill children at risk of severe organ dysfunction.
How similar studies have performed: Previous research has shown promising results in using similar physiological markers to predict outcomes in critically ill patients, suggesting that this approach may be effective.
Where this research is happening
LOS ANGELES, UNITED STATES
- CHILDREN'S HOSPITAL OF LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHALLA, ANOOPINDAR — CHILDREN'S HOSPITAL OF LOS ANGELES
- Study coordinator: BHALLA, ANOOPINDAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.