Investigating a liver-specific protein that helps control energy balance
Official title: A liver-specific mitochondrial carrier that controls energy homeostasis
Funded at Beth Israel Deaconess Medical Center · NIH-10818863 · Data updated 2026-11-12
This study is looking at a special protein in the liver that helps control energy and sugar levels in the body, and it's trying to find out if blocking this protein could help people with obesity and high blood sugar.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $511,336 |
| NIH project number | 1R01DK138529-01 |
| Project ID | NIH-10818863 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals struggling with obesity or high blood sugar levels.
✕Less likely to help
Patients with metabolic conditions unrelated to liver function may not benefit from this research.
What this research studies
This research focuses on a unique protein found in the liver that plays a crucial role in managing energy levels in the body. The study aims to understand how this protein, known as SLC25A47, affects the production of glucose and overall energy expenditure, particularly during fasting. By exploring the mechanisms behind this protein's action, the researchers hope to determine if inhibiting it can help treat conditions like obesity and high blood sugar. Patients may benefit from insights that could lead to new therapies targeting this specific protein.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and hyperglycemia by targeting a liver-specific protein.
How similar studies have gone: Other research has shown promising results in targeting specific proteins for metabolic diseases, suggesting potential success for this approach.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Kajimura, Shingo — Beth Israel Deaconess Medical Center
- Study coordinator: Kajimura, Shingo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.