Investigating a lipid kinase's role in chronic lymphocytic leukemia
Official title: Pro-Oncogenic Role of a Mitochondrial Lipid Kinase in CLL
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10825589 · Data updated 2026-11-12
This study is looking at a protein called acylglycerol kinase (AGK) that is found in higher amounts in some people with chronic lymphocytic leukemia (CLL), to see how it affects the disease and could help find better treatments for patients like you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 10, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $193,195 |
| NIH project number | 5R21CA280437-02 |
| Project ID | NIH-10825589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with chronic lymphocytic leukemia, particularly those who have not yet received therapy.
✕Less likely to help
Patients with other types of leukemia or those who have already undergone extensive treatment for CLL may not benefit from this research.
What this research studies
This research focuses on chronic lymphocytic leukemia (CLL), a type of cancer affecting B-cells. It aims to understand the role of a specific mitochondrial lipid kinase, acylglycerol kinase (AGK), which has been found to be highly expressed in many CLL patients. By exploring how AGK contributes to the development and resistance of CLL, the research seeks to uncover new insights into the disease's biology. This could lead to improved treatment strategies for patients suffering from CLL.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating chronic lymphocytic leukemia more effectively.
How similar studies have gone: Other research has shown promising results in targeting similar oncogenic pathways in various cancers, indicating potential for success in this area as well.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Ghosh, Asish Kumar — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Ghosh, Asish Kumar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.