Investigating a key protein's role in DNA repair
Official title: Drosophila Nse5/6: a missing link for heterochromatin repair
Funded at University of Southern California · NIH-11074784 · Data updated 2026-11-12
This study is looking at how a special protein complex helps fix DNA damage in cells, especially in tricky areas of our genes, to keep our cells healthy and working properly.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $456,500 |
| NIH project number | 1R21ES036346-01A1 |
| Project ID | NIH-11074784 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with a history of cancer or genetic disorders that involve DNA repair issues.
✕Less likely to help
Patients with conditions unrelated to DNA repair or those who do not have genetic predispositions to DNA damage may not benefit from this research.
What this research studies
This research focuses on understanding how a specific protein complex, Nse5/6, contributes to the repair of DNA damage in cells, particularly in challenging regions of the genome known as heterochromatin. The study examines how this complex helps prevent errors during DNA repair processes that can lead to genome instability, which is crucial for maintaining healthy cell function. By using advanced biological models, the research aims to uncover the mechanisms behind DNA repair and how they can be influenced by environmental factors or normal cellular activities. This could provide insights into how cells manage DNA damage and maintain genetic integrity.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing DNA repair mechanisms, potentially benefiting patients with cancer or genetic disorders linked to DNA repair deficiencies.
How similar studies have gone: Other research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Chiolo, Irene E — University of Southern California
- Study coordinator: Chiolo, Irene E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.