Investigating a key enzyme involved in DNA repair and cancer
Cell line Core
This study is looking at a special enzyme that helps fix broken DNA, which is important for understanding cancer better, and it aims to improve lab tests that could lead to better treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10868631 on NIH RePORTER |
What this research studies
This research focuses on understanding mammalian DNA polymerase θ, an enzyme crucial for repairing DNA double-strand breaks, which are often linked to cancer. The project includes a specialized core that will provide both native and genetically engineered cell lines to support various cell-based assays. By implementing standardized protocols for cell line validation and genome manipulation, the research aims to enhance the reliability of laboratory experiments. Patients may benefit from advancements in cancer treatment through improved understanding of DNA repair mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with cancers that involve DNA repair deficiencies.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted therapies for cancer patients by improving our understanding of DNA repair processes.
How similar studies have performed: Other research has shown success in utilizing CRISPR technology for genome engineering, indicating a promising approach in this area.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Gupta, Gaorav P. — Univ of North Carolina Chapel Hill
- Study coordinator: Gupta, Gaorav P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.