Investigating a key enzyme in eye disease-related scarring
Official title: RPE PFKFB3 in subretinal fibrosis
Funded at Augusta University · NIH-10912760 · Data updated 2026-11-12
This study is looking at how a certain enzyme affects the growth of scar tissue in the eye that can cause vision loss for people with age-related macular degeneration, and it hopes to find new ways to prevent this scarring and help keep your vision healthy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $115,471 |
| NIH project number | 5K99EY034577-02 |
| Project ID | NIH-10912760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neovascular age-related macular degeneration who are experiencing or at risk of developing subretinal fibrosis.
✕Less likely to help
Patients with other forms of macular degeneration or those without any retinal conditions may not benefit from this research.
What this research studies
This research focuses on understanding how a specific enzyme, PFKFB3, contributes to the development of subretinal fibrosis, a condition that can lead to severe vision loss in patients with age-related macular degeneration. The study aims to explore the metabolic pathways involved in this process, particularly how certain cells in the eye become activated and contribute to scarring. By examining the role of glycolysis and the behavior of retinal pigment epithelium cells, the research seeks to identify potential therapeutic strategies to inhibit this fibrosis and preserve vision.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce vision loss caused by subretinal fibrosis.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in other fibrotic conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Yang, Qiuhua — Augusta University
- Study coordinator: Yang, Qiuhua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.