Investigating a key enzyme in blood vessel changes related to high blood pressure
Official title: Vascular Pyruvate Kinase M2 in Hypertension
Funded at Temple Univ of the Commonwealth · NIH-11050618 · Data updated 2026-11-12
This study is looking at how a special enzyme affects blood vessel changes in people with high blood pressure, with the hope of finding new treatments to help manage their condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $732,119 |
| NIH project number | 1R01HL174004-01A1 |
| Project ID | NIH-11050618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with hypertension, particularly those who may not be adequately controlled on current therapies.
✕Less likely to help
Patients with normal blood pressure or those whose hypertension is well-managed with existing treatments may not benefit from this research.
What this research studies
This research focuses on understanding how a specific enzyme, pyruvate kinase M2, influences changes in blood vessels associated with hypertension. By examining the role of this enzyme in vascular smooth muscle cells, the study aims to uncover mechanisms that contribute to the remodeling of blood vessels in patients with high blood pressure. The ultimate goal is to identify potential new therapies that could be added to existing treatments for hypertension, improving patient outcomes. The research will involve both laboratory experiments and analysis of cellular responses to angiotensin II, a hormone that plays a significant role in regulating blood pressure.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that better manage hypertension and reduce the risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding metabolic shifts in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Eguchi, Satoru — Temple Univ of the Commonwealth
- Study coordinator: Eguchi, Satoru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.