Investigating a hormone's role in obesity-related high blood pressure
Official title: Angiotensin-(1-7) and Cardiovascular Derangements in Obesity Hypertension
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-11072989 · Data updated 2026-11-12
This study is looking at how a hormone called angiotensin-(1-7) might help people with obesity lower their blood pressure and improve their overall health, and it’s for anyone interested in new ways to manage these conditions without harmful side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | April 15, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $647,738 |
| NIH project number | 5R01HL170140-02 |
| Project ID | NIH-11072989 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are obese individuals who are experiencing hypertension.
✕Less likely to help
Patients who are not obese or do not have hypertension may not benefit from this research.
What this research studies
This research explores the relationship between obesity and hypertension, focusing on a hormone called angiotensin-(1-7) that may help lower blood pressure and improve metabolic health. The study involves both animal models and preliminary human data to assess how angiotensin-(1-7) affects cardiovascular function and insulin sensitivity in obese individuals. By understanding the mechanisms at play, the research aims to identify new treatment options that do not have negative metabolic side effects.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively manage high blood pressure in obese patients without harmful metabolic consequences.
How similar studies have gone: While there is limited clinical data on angiotensin-(1-7) in humans, preliminary findings suggest potential benefits, indicating that this approach is promising but not yet fully tested.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Arnold, Amy Christine — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Arnold, Amy Christine
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.