Investigating a hormone linked to heart failure and its effects on patients
Growth differentiation factor-15 (GDF15) as a novel myocardial hormone in heart failure
This study is looking at how a protein called GDF15 affects heart failure in people with dilated cardiomyopathy, especially focusing on a serious condition called cardiac cachexia that can make life tougher and increase health risks, with the goal of finding new ways to help treat these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11020955 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Growth Differentiation Factor 15 (GDF15) in heart failure, particularly in patients with dilated cardiomyopathy. It aims to uncover the molecular mechanisms behind cardiac cachexia, a serious complication that affects quality of life and increases mortality risk. By studying how GDF15 functions in the heart and its potential impact on heart failure progression, the research seeks to identify new treatment strategies. The approach includes analyzing biological samples and utilizing animal models to explore the pathways involved in this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy and experiencing symptoms of heart failure.
Not a fit: Patients without heart failure or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the quality of life and survival rates for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding the role of GDF15 in other chronic diseases, indicating potential for success in this novel approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Burke, Michael a — Emory University
- Study coordinator: Burke, Michael a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.