Investigating a genetic variant's role in liver injury from alcohol consumption
The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury
This study is looking at how a certain gene might influence liver damage from alcohol, using special mice that have similar liver issues as humans, to help find better treatments for people with alcohol-related liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11055411 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific genetic variant in the PNPLA3 gene affects liver damage caused by alcohol. Researchers are using advanced mouse models that mimic human liver conditions to explore the mechanisms behind this genetic variant and its impact on liver inflammation and fibrosis. By studying these models, the research aims to uncover the biological processes that lead to alcohol-related liver disease, which could help in developing targeted treatments for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol consumption who may have the PNPLA3-148M genetic variant.
Not a fit: Patients who do not consume alcohol or do not have the PNPLA3-148M variant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from alcohol-related liver disease.
How similar studies have performed: Previous studies have shown significant associations between the PNPLA3 variant and liver disease, indicating that this research builds on established findings in the field.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Dong, X. Charlie — Indiana University Indianapolis
- Study coordinator: Dong, X. Charlie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.