Investigating a genetic variant's role in familial brain tumors
Official title: Defining the role of germline Daam2 variant R414W in familial glioma
Funded at Baylor College of Medicine · NIH-11070752 · Data updated 2026-11-12
This study is looking at how a certain change in the Daam2 gene might play a role in causing familial glioma, a type of brain tumor that runs in families, to help find better ways to prevent and treat it for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 3, 2025 |
| Project end | November 2, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31NS141637-01 |
| Project ID | NIH-11070752 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of glioma or those who have been diagnosed with familial glioma.
✕Less likely to help
Patients with sporadic glioma without any familial connection may not benefit directly from this research.
What this research studies
This research focuses on understanding how a specific genetic variant in the Daam2 gene may contribute to the development of familial glioma, a type of brain tumor. Researchers will analyze the effects of this variant on tumor growth and progression, aiming to uncover the underlying mechanisms that lead to glioma in patients with a family history of the disease. By studying the relationship between Daam2 mutations and glioma, the research seeks to provide insights that could lead to better prevention and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of familial glioma, potentially offering new avenues for treatment and prevention.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors in other cancers, suggesting that this approach could yield valuable insights for glioma as well.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Choy, Tiffany Jiyan — Baylor College of Medicine
- Study coordinator: Choy, Tiffany Jiyan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.