Investigating a genetic variant's impact on hearing in the inner ear
Effects of the TECTB-C225Y Variant in the Inner Ear
['FUNDING_FELLOWSHIP'] · HARVARD MEDICAL SCHOOL · NIH-11062794
This study is looking at how a specific gene change affects hearing by using mice that have this change, and it aims to help us understand hearing loss better so we can find new ways to treat it.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD MEDICAL SCHOOL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11062794 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific genetic variant, TECTB-C225Y, affects hearing function. Using a mouse model that mimics this genetic mutation, researchers will assess auditory function through various tests, including auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE). The study aims to characterize the hearing impairment associated with this variant and explore its underlying mechanisms, which could lead to new therapeutic strategies for hearing loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of autosomal-dominant hearing loss, particularly those with the TECTB-C225Y variant.
Not a fit: Patients with hearing loss not linked to genetic factors or those without the TECTB-C225Y variant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with genetic hearing loss.
How similar studies have performed: Previous research has shown success in using genetic mouse models to study hearing loss, indicating that this approach is promising.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD MEDICAL SCHOOL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HALE, EVAN BROWN — HARVARD MEDICAL SCHOOL
- Study coordinator: HALE, EVAN BROWN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.