Investigating a genetic variant that may increase lung cancer risk in Black Americans
Analysis of a missense SNP in the aryl hydrocarbon receptor repressor gene that may disproportionately increase lung cancer risk in Black Americans
['FUNDING_R21'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11059064
This study is looking at a specific gene change that might affect how Black Americans process harmful substances from tobacco smoke, helping us understand why lung cancer rates are higher in this group, and your participation could help find better ways to prevent this disease in your community.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11059064 on ClinicalTrials.gov |
What this research studies
This research focuses on a specific genetic variation, known as a single nucleotide polymorphism (SNP), in the aryl hydrocarbon receptor repressor (AHRR) gene, which may affect lung cancer risk among Black Americans. The study aims to understand how this SNP influences the body's ability to detoxify harmful substances from tobacco smoke, which is particularly relevant given the higher lung cancer rates observed in this population. By analyzing genetic samples and their association with lung cancer incidence, the research seeks to uncover important links that could lead to better prevention strategies. Participants may contribute to a deeper understanding of genetic factors influencing lung cancer risk in their community.
Who could benefit from this research
Good fit: Ideal candidates for this research are Black American individuals, particularly men, who may have a family history of lung cancer or are current or former smokers.
Not a fit: Patients who are not of Black American descent or those without a history of smoking may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for lung cancer in Black Americans.
How similar studies have performed: While this specific SNP has not been extensively studied before, preliminary data suggests potential associations with smoking-related cancers in Black Americans, indicating a novel area of investigation.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OFFRINGA, ITE A — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: OFFRINGA, ITE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.