Investigating a genetic region linked to type 1 and type 2 diabetes.
Official title: Functionalizing a T1D/T2D-associated locus within an intron of GLIS3.
Funded at University of Wisconsin-Madison · NIH-10930825 · Data updated 2026-11-12
This study is looking at how certain genes, especially one called GLIS3, might affect the risk of developing type 1 and type 2 diabetes, using both human and mouse data to learn more about how these genes influence blood sugar and insulin levels, which could help find better treatments for diabetes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $36,918 |
| NIH project number | 5F31DK137447-02 |
| Project ID | NIH-10930825 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of type 1 or type 2 diabetes or those diagnosed with these conditions.
✕Less likely to help
Patients without a genetic predisposition to diabetes or those with other unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic regions contribute to the development of type 1 and type 2 diabetes. By examining a particular locus within the GLIS3 gene, researchers will utilize both human and mouse genetic data to explore its role in diabetes susceptibility. The study involves creating a novel mouse model to observe the effects of genetic alterations on blood sugar levels and insulin response. This approach aims to uncover new insights into the mechanisms behind diabetes, potentially leading to improved treatment options.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of diabetes, potentially improving treatment strategies for patients.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in diabetes, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Clark, Lauren Elizabeth — University of Wisconsin-Madison
- Study coordinator: Clark, Lauren Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.