Investigating a genetic mutation in the p53 protein linked to cancer risk
The genetics of tumor suppression by p53
['FUNDING_R01'] · WISTAR INSTITUTE · NIH-11053342
This study is looking at a specific change in a protein called p53 that some families with a lot of cancer cases have, to see how it might affect the body's ability to prevent tumors, especially in kids with adrenal tumors, and it hopes to help us understand more about cancer risks for those with this mutation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WISTAR INSTITUTE (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11053342 on ClinicalTrials.gov |
What this research studies
This research focuses on a specific mutation in the p53 protein, known as G334R, which has been identified in families with a high incidence of various cancers, including pediatric adrenal tumors. The study aims to understand how this mutation affects the protein's ability to suppress tumor formation and its overall function in cancer biology. By analyzing tumor samples and conducting functional assays, researchers will explore the implications of this mutation on cancer predisposition and tumor suppression. Patients with this mutation may provide valuable insights into the genetic mechanisms of cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from families with a history of multiple cancers, particularly those with the G334R mutation in the p53 gene.
Not a fit: Patients without a family history of cancer or those who do not carry the G334R mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer predisposition and potential new strategies for prevention and treatment.
How similar studies have performed: Previous research has shown success in understanding the role of p53 mutations in cancer, making this approach both relevant and promising.
Where this research is happening
PHILADELPHIA, UNITED STATES
- WISTAR INSTITUTE — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MURPHY, MAUREEN E. — WISTAR INSTITUTE
- Study coordinator: MURPHY, MAUREEN E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: anti-cancer research