Investigating a gene's role in fat storage, aging, and reproduction
The mechanistic role of metabolic gene MTCH2/mtch-1 in lipid homeostasis, longevity, and fertility
This study is looking at how a specific gene called MTCH2 influences how our bodies store fat, how long we live, and our ability to have children, with the goal of finding new ways to help people struggling with obesity and related health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10650721 on NIH RePORTER |
What this research studies
This research focuses on understanding how the MTCH2 gene affects fat storage, longevity, and fertility. By studying the interactions between this gene and environmental factors, the research aims to uncover the genetic predispositions that contribute to obesity and related health issues. The approach involves using various model systems, including cells and animal models, to observe the effects of activating or inhibiting the MTCH2 gene on lipid accumulation and overall health. The findings could lead to new therapies aimed at reducing obesity and its associated diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are struggling with obesity or related metabolic conditions.
Not a fit: Patients who are not overweight or do not have obesity-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating obesity and its related health complications.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to obesity, indicating that this approach has potential for success.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Rottiers, Veerle — University of California Berkeley
- Study coordinator: Rottiers, Veerle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.