Investigating a gene's role in colon cell identity and regeneration
Official title: MTGs in Intestinal Biology and Injury Responses
Funded at Vanderbilt University Medical Center · NIH-11126705 · Data updated 2026-11-12
This study is looking at a gene called MTG16 and how it helps keep your colon cells healthy, especially when it comes to healing and dealing with diseases like inflammatory bowel disease (IBD), so that we can find better ways to support your gut health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $592,553 |
| NIH project number | 5R01DK131810-02 |
| Project ID | NIH-11126705 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory bowel disease or those experiencing colon-related health issues.
✕Less likely to help
Patients without any gastrointestinal conditions or those not affected by inflammatory bowel disease may not benefit from this research.
What this research studies
This research focuses on the Myeloid Translocation Gene on chromosome 16 (MTG16) and its influence on colon cell identity during normal function, healing, and disease. The study examines how MTG16 regulates the balance between different types of cells in the colon, particularly goblet and enteroendocrine cells, which are essential for gut health. By using advanced techniques, the researchers aim to uncover the mechanisms by which MTG16 affects these processes, potentially leading to new treatments for inflammatory bowel disease (IBD). Patients may benefit from insights gained about how to improve colon health and manage related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory bowel disease and improving colon health.
How similar studies have gone: Other research has shown promising results in understanding gene regulation in intestinal biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Williams, Christopher S. — Vanderbilt University Medical Center
- Study coordinator: Williams, Christopher S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.