Investigating a gene variant's role in Alzheimer's disease
Evaluating the functional consequences of Alzheimer's disease-associated variant CICP36L
['FUNDING_FELLOWSHIP'] · BAYLOR COLLEGE OF MEDICINE · NIH-10840939
This study is looking at a specific gene variant called CICP36L to see how it might play a role in the development of Alzheimer's disease, with the goal of finding new ways to help treat or prevent the condition.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10840939 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific gene variant, known as CICP36L, may contribute to the development of Alzheimer's disease (AD). The study aims to explore the functional consequences of this variant, particularly its impact on a protein complex that is crucial for brain health. By examining the interactions between this gene and other proteins, researchers hope to uncover mechanisms that lead to increased risk of AD, which could inform future treatments. The research involves genetic analysis and animal models to assess how changes in this gene affect AD pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who carry specific genetic risk factors associated with late-onset Alzheimer's.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's disease or who are not affected by neurodegenerative disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets for prevention or treatment.
How similar studies have performed: Previous research has shown success in identifying genetic variants associated with Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, HAMIN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: LEE, HAMIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia