Investigating a gene that regulates cell function and aging
Official title: Novel Zinc-Finger Protein Regulator of Senescence and Cell Engineering
Funded at University of Utah · NIH-11086767 · Data updated 2026-11-12
This study is looking at how a gene called ZNF865 affects how our cells work as we age, and it aims to use special technology to improve cell activity, which could help create better treatments for conditions related to aging and tissue repair.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 9, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $406,071 |
| NIH project number | 5R01AR083990-02 |
| Project ID | NIH-11086767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with degenerative conditions affecting their tissues, such as back pain or other musculoskeletal issues.
✕Less likely to help
Patients with acute injuries or conditions unrelated to cellular aging or degeneration may not receive benefit from this research.
What this research studies
This research explores the role of a gene called ZNF865 in regulating cell functions related to aging and tissue engineering. Using advanced CRISPR technology, the team aims to manipulate this gene to enhance cell activity and potentially improve therapies for various conditions. The study involves engineering cells to better understand how ZNF865 affects processes like cell division and senescence, which could lead to breakthroughs in treating degenerative diseases. Patients may benefit from new cell-based therapies that improve tissue regeneration and function.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance tissue repair and combat age-related cellular decline.
How similar studies have gone: Other research has shown promising results using CRISPR technology for gene regulation, indicating potential for success in this novel approach.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Bowles, Robert D. — University of Utah
- Study coordinator: Bowles, Robert D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.