Investigating a gene that may influence learning difficulties in neurofibromatosis
Official title: Metabotropic glutamate receptor 7 as a potential genetic modifier of cognitive deficits in neurofibromatosis
Funded at Vanderbilt University · NIH-11116196 · Data updated 2026-11-12
This study is looking at how a specific gene might influence learning and attention in children with neurofibromatosis type 1 (NF1), helping us understand more about the challenges they face and how to support them better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $237,399 |
| NIH project number | 1R21NS143120-01 |
| Project ID | NIH-11116196 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with neurofibromatosis type 1 who experience learning disabilities or attention deficit hyperactivity disorder.
✕Less likely to help
Patients without a diagnosis of neurofibromatosis type 1 or those who do not exhibit cognitive deficits may not benefit from this research.
What this research studies
This research focuses on neurofibromatosis type 1 (NF1), a genetic disorder that can lead to nerve tumors and learning disabilities. The study aims to explore the role of the metabotropic glutamate receptor 7 (mGlu7) in modifying cognitive deficits associated with NF1. By examining genetic variations, the researchers hope to understand how these may affect learning and attention in children with NF1. The approach includes analyzing genetic data and its correlation with cognitive outcomes in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for cognitive deficits in children with neurofibromatosis.
How similar studies have gone: Previous research has shown promising results in understanding genetic modifiers of cognitive functions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Niswender, Colleen M — Vanderbilt University
- Study coordinator: Niswender, Colleen M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.