Investigating a gene that may influence learning difficulties in neurofibromatosis
Metabotropic glutamate receptor 7 as a potential genetic modifier of cognitive deficits in neurofibromatosis
This study is looking at how a specific gene might influence learning and attention in children with neurofibromatosis type 1 (NF1), helping us understand more about the challenges they face and how to support them better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11116196 on NIH RePORTER |
What this research studies
This research focuses on neurofibromatosis type 1 (NF1), a genetic disorder that can lead to nerve tumors and learning disabilities. The study aims to explore the role of the metabotropic glutamate receptor 7 (mGlu7) in modifying cognitive deficits associated with NF1. By examining genetic variations, the researchers hope to understand how these may affect learning and attention in children with NF1. The approach includes analyzing genetic data and its correlation with cognitive outcomes in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with neurofibromatosis type 1 who experience learning disabilities or attention deficit hyperactivity disorder.
Not a fit: Patients without a diagnosis of neurofibromatosis type 1 or those who do not exhibit cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for cognitive deficits in children with neurofibromatosis.
How similar studies have performed: Previous research has shown promising results in understanding genetic modifiers of cognitive functions, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Niswender, Colleen M — Vanderbilt University
- Study coordinator: Niswender, Colleen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.