Investigating a gene linked to neurodevelopmental disorders using a mouse model
Official title: Preliminary Functional Studies of an Understudied NDD Gene in Mice
Funded at University of Alabama at Birmingham · NIH-10726239 · Data updated 2026-11-12
This study is looking at how a certain gene linked to conditions like autism and intellectual disability affects behavior and brain function, using specially modified mice to help find new ways to treat these disorders.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $148,500 |
| NIH project number | 1R03MH133908-01 |
| Project ID | NIH-10726239 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with neurodevelopmental disorders such as autism or intellectual disability.
✕Less likely to help
Patients with neurodevelopmental disorders not linked to the specific gene being studied may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of a specific gene associated with neurodevelopmental disorders such as autism and intellectual disability. By using a genetically modified mouse model, researchers will conduct behavioral tests to observe how changes in this gene affect brain function and behavior. Additionally, they will analyze brain tissue to identify genetic and molecular changes that occur due to the mutation. The findings aim to provide insights that could lead to new treatment strategies for these disorders.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for neurodevelopmental disorders, improving outcomes for affected individuals.
How similar studies have gone: Previous research has shown success in using genetic mouse models to uncover mechanisms of neurodevelopmental disorders, suggesting this approach is promising.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Powell, Craig M — University of Alabama at Birmingham
- Study coordinator: Powell, Craig M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.