Investigating a gene linked to coronary artery disease
Mechanistic Studies of the Novel Human Coronary Artery Disease Gene SVEP1
This study is looking at how a specific gene called SVEP1 might play a role in heart disease, especially for people who are at risk of coronary artery disease, to help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11017699 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the SVEP1 gene in coronary artery disease (CAD), which is a major cause of heart-related health issues. The study utilizes genetic association techniques to identify how variations in the SVEP1 gene affect the development of CAD, independent of traditional cholesterol levels. By creating mouse models that lack the SVEP1 gene, researchers aim to uncover the mechanisms by which this gene influences vascular smooth muscle cells and contributes to atherosclerosis. The ultimate goal is to identify new therapeutic targets that could lead to better treatments for patients at risk of CAD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of coronary artery disease or those who have been diagnosed with atherosclerosis but have normal cholesterol levels.
Not a fit: Patients who do not have any genetic predisposition to coronary artery disease or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the mechanisms of coronary artery disease, potentially reducing the risk for many patients.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to coronary artery disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Stitziel, Nathan Oliver — Washington University
- Study coordinator: Stitziel, Nathan Oliver
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.