Investigating a female-specific neural pathway that influences social behaviors in mice
Functional dissection of a molecularly identified female-specific neural pathway in mice
This study is looking at how certain brain cells in female mice, which are affected by hormones like progesterone and estrogen, influence their social behaviors, like being friendly or aggressive, to help us understand more about how these behaviors work in females.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10850668 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific neurons in the brain, particularly those influenced by hormones like progesterone and estrogen, control social behaviors in female mice. By using advanced genetic techniques, the study aims to identify and characterize a unique population of neurons that are active only in females and explore their role in behaviors such as aggression and courtship. The researchers will employ deep sequencing to analyze these neurons and their impact on social interactions, which are crucial for mental well-being and reproductive success.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals interested in the biological underpinnings of social behaviors and those affected by related behavioral disorders.
Not a fit: Patients who do not identify with the biological sex differences being studied or those with unrelated behavioral conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological basis of social behaviors, potentially informing treatments for behavioral disorders.
How similar studies have performed: Other research has shown success in linking specific neural circuits to behaviors, but this particular focus on female-specific pathways is relatively novel.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Shah, Nirao Mahesh — Stanford University
- Study coordinator: Shah, Nirao Mahesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.