Investigating a drug to promote healthy aging.
Clinical evaluation of mTORC1 inhibition for geroprotection.
This study is looking at whether a medication called everolimus can help people age healthier by testing different low doses over six months, and it's for anyone interested in improving their health as they get older.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10886063 on NIH RePORTER |
What this research studies
This research evaluates the effects of a drug called everolimus, which inhibits a protein complex known as mTORC1, on healthy aging in humans. The study aims to determine if low-dose or intermittent dosing of this drug can safely improve health outcomes related to aging. Participants will receive either daily or weekly doses over a 24-week period, and researchers will monitor physiological and molecular changes to assess the drug's effectiveness and safety. The goal is to find a way to enhance healthy aging while minimizing side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are interested in interventions for healthy aging.
Not a fit: Patients who are not experiencing age-related conditions or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that promote healthier aging and reduce the risk of age-related diseases.
How similar studies have performed: Previous research has shown that mTORC1 inhibition can extend lifespan and improve health in animal models, but this approach is still being tested in humans.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Konopka, Adam R — University of Wisconsin-Madison
- Study coordinator: Konopka, Adam R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.