Investigating a dietary supplement for Crohn's Disease management
Dosing and Pilot Efficacy of 2'-Fucosyllactose in Inflammatory Bowel Disease
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-10982152
This study is looking at whether a special prebiotic called 2'-fucosyllactose can help kids and young adults with Crohn's Disease stay healthy and avoid flare-ups while they are on their current treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10982152 on ClinicalTrials.gov |
What this research studies
This research focuses on the use of a prebiotic called 2'-fucosyllactose (2'-FL) to help maintain remission in patients with Crohn's Disease (CD). The study will involve pediatric and young adult patients who are currently stable on anti-TNF therapy. Participants will receive either 1g or 5g of 2'-FL or a placebo daily, and the research will assess the safety, tolerability, and effects on gut microbiota. By monitoring clinical symptoms and fecal markers, the study aims to determine if 2'-FL can improve gut health and prevent relapses.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric and young adult patients with Crohn's Disease who are currently in stable remission and receiving anti-TNF therapy.
Not a fit: Patients who are not currently in remission or those not receiving anti-TNF therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new dietary approach to help maintain remission in Crohn's Disease patients.
How similar studies have performed: Previous research has shown promise in using prebiotics to improve gut health, making this approach a potentially valuable addition to Crohn's Disease management.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENSON, LEE ARMISTEAD — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: DENSON, LEE ARMISTEAD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.