Investigating a crucial protein in malaria transmission stages
Functional investigation of a novel and essential subcellular compartment in Plasmodium falciparum transmission stage parasites
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-11042736
This study is looking at a protein called PfBLEB to see how it helps malaria parasites grow and spread, which could help us find new ways to prevent and treat malaria.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11042736 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific protein, PfBLEB, is essential for the development of malaria parasites known as gametocytes, which are responsible for transmitting the disease. By studying the changes in the parasites during their maturation in human red blood cells, researchers aim to uncover the mechanisms that allow these parasites to infect new hosts. The approach involves manipulating the expression of PfBLEB to observe its effects on gametocyte formation and morphology. This could lead to insights into potential targets for malaria prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are at risk of malaria infection.
Not a fit: Patients who are not affected by malaria or are over the age of 11 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing malaria transmission, ultimately reducing the incidence of the disease.
How similar studies have performed: Previous research has shown success in targeting specific proteins in malaria parasites, indicating that this approach may yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DVORIN, JEFFREY D — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: DVORIN, JEFFREY D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.