Investigating a complex that helps suppress tumors and viruses by maintaining DNA integrity
Single-molecule dissection of a tumor- and virus-suppressing Smc complex involved in genome maintenance
This study is looking at a special protein complex that helps keep our DNA healthy and prevents problems like tumors and viruses, and by understanding how it works, we hope to find new ways to tackle issues related to cancer and DNA damage.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10844480 on NIH RePORTER |
What this research studies
This research focuses on understanding the structural maintenance of chromosomes (Smc) 5/6 complex, which plays a vital role in preventing tumors and suppressing viruses like hepatitis B. By examining how this complex operates at a molecular level, the research aims to uncover its mechanisms in DNA replication and repair. Using advanced techniques such as single-molecule fluorescence and force microscopy, the study will analyze how Smc5/6 interacts with DNA and its components. This knowledge could lead to new strategies for addressing genome instability and cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with endometrial cancer or those at risk for cancers linked to DNA repair deficiencies.
Not a fit: Patients with cancers unrelated to DNA repair mechanisms or those not affected by the Smc5/6 complex may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers associated with genome instability.
How similar studies have performed: While the specific approach of dissecting the Smc5/6 complex is novel, similar studies on DNA repair mechanisms have shown promising results in understanding cancer biology.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Chang, Jeremy Tzu-Huai — Weill Medical Coll of Cornell Univ
- Study coordinator: Chang, Jeremy Tzu-Huai
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.