Investigating a blood biomarker for Alzheimer's disease in aging macaques
Generation and trans-neuronal seeding of phosphorylated T217-Tau in aging macaque cortical circuits
This study is looking at a special blood marker called pT217-tau to see how it relates to Alzheimer's disease as the brain ages, using older monkeys to help find out when and where this marker shows up in the brain, which could help spot early signs of memory problems before they start.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10524449 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific blood biomarker, pT217-tau, is produced in the aging brain and its connection to Alzheimer's disease. Using a unique model of aging rhesus macaques, the study will explore the timing and location of pT217-tau expression in different brain regions. By examining the relationship between this biomarker and neuronal degeneration, researchers aim to uncover critical insights into the progression of Alzheimer's disease. The findings could help identify early indicators of cognitive decline long before symptoms appear.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those at risk for Alzheimer's disease or showing early signs of cognitive decline.
Not a fit: Patients who are younger than 21 or do not have any risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Alzheimer's disease, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using biomarkers for early detection of Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Datta, Dibyadeep — Yale University
- Study coordinator: Datta, Dibyadeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.