Investigating 17 alpha-estradiol as a potential treatment for Alzheimer's disease
Official title: 17 alpha-estradiol as a potential protective therapeutic against development of Alzheimer's disease
Funded at University of Southern California · NIH-10930827 · Data updated 2026-11-12
This study is looking at how a substance called 17 alpha-estradiol might help protect against aging and Alzheimer's disease, especially for people with a specific gene that increases their risk, using mice to see how it works.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AG084279-02 |
| Project ID | NIH-10930827 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with the APOE4 genotype or those at risk for Alzheimer's disease due to aging.
✕Less likely to help
Patients without the APOE4 genotype or those who do not exhibit risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research explores the effects of 17 alpha-estradiol (17αE2) on aging and Alzheimer's disease, particularly in individuals with the APOE4 genotype, which is a significant risk factor for developing the disease. The study will utilize mouse models to assess how 17αE2 may protect against age-related changes that contribute to Alzheimer's pathology. By examining both systemic and neural impacts of this treatment, the research aims to identify potential benefits for both male and female mice with different APOE genotypes. The findings could provide insights into new therapeutic strategies for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new protective therapies for individuals at risk of developing Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results with similar approaches, particularly in animal models, but this specific application of 17αE2 is relatively novel.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Mcgill, Cassandra Joan — University of Southern California
- Study coordinator: Mcgill, Cassandra Joan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.