Intraoperative Cardiac Pulsed Field Ablation and Lesion Assessment System
Funded at Sigt, LLC · NIH-11409042 · Data updated 2026-11-12
A device-focused project aims to help doctors perform safer, more precise pulsed field ablation for atrial fibrillation by providing real-time lesion assessment during surgery.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sigt, LLC NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 1, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $848,381 |
| NIH project number | 1R44HL186984-01 |
| Project ID | NIH-11409042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with atrial fibrillation undergoing ablation who may benefit from precision lesion creation and intraoperative feedback.
✕Less likely to help
Patients not undergoing ablation or those not considered candidates for PFA may not directly benefit from this device-focused project.
What this research studies
This project develops a clinical-grade Cardiac PFA-LAS system to measure lesion formation during pulsed field ablation for atrial fibrillation. It uses High Frequency Dielectric Sensing to guide the delivery of ablation pulses and confirm durable lesions intraoperatively. The effort focuses on translating lab-developed HFDS technology into a usable surgical tool that can improve accuracy, reduce collateral injury, and potentially lower the need for repeat procedures. This is a Phase II SBIR aimed at creating a practical, patient-facing technology that surgeons can adopt in the operating room.
Why it matters
Potential benefit: If successful, patients with AF could benefit from safer, more effective ablation procedures with fewer complications and repeat procedures.
How similar studies have gone: Previous work has shown promise for dielectric sensing in lab settings, but clinical-grade, intraoperative lesion assessment is an emerging area with limited real-world validation.
Where this research is happening
-
Sigt, LLC
Columbia, United States Active
Researchers
- Principal investigator: Karmarkar, Parag — Sigt, LLC
- Study coordinator: Karmarkar, Parag
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.