Interstrand crosslinks from repairing etheno DNA adducts
Official title: Interstrand crosslinks generated from the repair of etheno DNA adducts
Funded at University of Rhode Island · NIH-11341352 · Data updated 2026-11-12
Aims to understand how certain DNA repair problems create harmful crosslinks that can disrupt cell growth and may lead to cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rhode Island NIH-funded |
| Lab location | 1 site (Kingston, United States) |
| Project start | September 18, 2026 |
| Project end | September 17, 2030 |
| Funding year | 2026 |
| Award (this year) | $3,822,478 |
| NIH project number | 1R01ES038526-01 |
| Project ID | NIH-11341352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly in this basic science grant; findings may inform future human studies.
✕Less likely to help
No immediate patient involvement or benefit in the current study.
What this research studies
This project investigates a surprising byproduct of repairing εA lesions in DNA, where covalent links form between DNA strands. Researchers will map these crosslinks (the etheno-adduct crosslinkome) and study how they arise during BER and direct reversal repair. Using cell models and advanced detection methods, the team will characterize the chemistry, formation conditions, and biological consequences of these crosslinks. Insights could reveal new pieces of how DNA damage promotes cancer and point to targets for therapy or prevention.
Why it matters
Potential benefit: Better understanding of DNA damage and repair could lead to new strategies to prevent or treat cancers linked to environmental and lipid-derived DNA lesions.
How similar studies have gone: Preliminary findings suggest crosslink formation from repair processes is biologically relevant, with ongoing research expanding this area.
Where this research is happening
-
University of Rhode Island
Kingston, United States Active
Researchers
- Principal investigator: Li, Deyu — University of Rhode Island
- Study coordinator: Li, Deyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.