Interpreting tumor DNA to help guide cancer care
The joint WCM-NYGC Center for Functional and Clinical Interpretation of Tumor Profiles
['FUNDING_OTHER'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11167466
This project combines advanced DNA and RNA analysis with clinical records to find which tumor mutations matter for people with cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11167466 on ClinicalTrials.gov |
What this research studies
If you have cancer, researchers will combine your tumor's DNA and RNA data with new computer methods to find mutations that drive disease and those that are likely harmless. They will examine both coding and non-coding changes, complex structural variants, copy number and tumor purity, and use linked-read sequencing and algorithms to separate cell types in mixed tumor samples. The team will connect these genetic findings with clinical information such as treatment responses to make the results more useful for care. The end goal is clearer tumor reports that could help doctors choose treatments or trials.
Who could benefit from this research
Good fit: People with cancer who have had or are willing to share tumor sequencing (DNA/RNA) data and related clinical information are ideal candidates to benefit from this work.
Not a fit: Patients without tumor sequencing data or those with non-cancer conditions are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could lead to clearer interpretation of tumor tests so doctors can better match patients to treatments or clinical trials.
How similar studies have performed: Previous genomic annotation efforts have identified actionable mutations in some cancers, but comprehensive interpretation of non-coding and complex structural variants is still an emerging area.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELEMENTO, OLIVIER — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: ELEMENTO, OLIVIER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers