Interactive exercise-and-brain game to slow thinking decline in Parkinson's disease

Neuro-exergaming for the Prevention and Remediation of Decline due to Parkinson's Disease: Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES v3)

NIH-funded research Ipaces, LLC · NIH-11145817

A home-friendly video exercise game that pairs pedaling with mental tasks to help people with Parkinson's disease keep thinking skills sharper.

Quick facts

Grant typeSbir 2 grant
Study typeNIH-funded research
Funding institutionIpaces, LLC NIH-funded
Lab location1 site (Clifton Park, United States)
Project IDNIH-11145817 on NIH RePORTER

What this research studies

You would use an interactive system (iPACES v3) that combines physical activity (like pedaling) with on-screen cognitive challenges designed for home use. Participants are typically asked to use the system regularly over weeks to months while researchers measure memory, thinking, and daily function before and after the program. The project compares results to a control condition so investigators can see whether the combined physical-and-cognitive game helps more than usual activity. Measurements may include standard cognitive tests and questionnaires about everyday abilities.

Who could benefit from this research

Good fit: Ideal candidates are people with Parkinson's disease who are experiencing early or mild cognitive changes and who can safely use a pedaling/exercise device at home.

Not a fit: People with advanced dementia, severe mobility or balance limitations, unstable medical problems, or who cannot operate the device are unlikely to benefit from this program.

Why it matters

Potential benefit: If successful, the program could help slow cognitive decline or improve thinking and daily functioning in people with Parkinson's disease.

How similar studies have performed: Earlier trials of exergaming in older adults have shown cognitive benefits, though using this specific combined approach for Parkinson's disease is relatively new.

Where this research is happening

Clifton Park, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndromeAlzheimer's Disease
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.