Interactions between opioids and a drug used for HIV prevention
Title: Pharmacokinetic, pharmacodynamic , and toxicological interactions among Opioids and Cabotegravir
This study is looking at how morphine, a common pain medication, works with cabotegravir, a drug that helps prevent HIV, to make sure it's safe for people who use opioids and are at risk for HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida International University NIH-funded |
| Lab location | 1 site (Miami, United States) |
| Project ID | NIH-10891599 on NIH RePORTER |
What this research studies
This research investigates how opioids, specifically morphine, interact with cabotegravir, a medication used for HIV prevention, in patients with opioid use disorders. The study focuses on understanding the potential risks of drug-drug interactions that could lead to toxicity, particularly in individuals who are at high risk for HIV. By examining how these drugs are metabolized in the body, the research aims to identify safer treatment protocols for patients who may be using both opioids and HIV prevention medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with opioid use disorders who are at high risk for HIV and may be using cabotegravir for HIV prevention.
Not a fit: Patients who do not have opioid use disorders or are not at risk for HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer medication guidelines for patients with opioid use disorders who are also at risk for HIV.
How similar studies have performed: Previous research has indicated potential risks associated with drug interactions between opioids and antiretroviral therapies, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
Miami, United States
- Florida International University — Miami, United States (Active)
Researchers
- Principal investigator: El-Hage, Nazira — Florida International University
- Study coordinator: El-Hage, Nazira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.