Interactions between human neural stem cells and blood vessel cells
Human neural stem cell and endothelial cell reciprocal interactions govern cell function
This study is looking at how special brain cells that help with healing interact with the cells that make up blood vessels, which could help us find better treatments for brain injuries and other neurological issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10906833 on NIH RePORTER |
What this research studies
This research investigates how human neural stem/progenitor cells (NSPCs) interact with endothelial cells (ECs) that form blood vessels in the brain. By using a 3D tissue engineering approach, the study aims to understand the complex relationships between these cell types, which are crucial for brain function and repair after injury. The researchers will explore how contact with ECs influences the behavior of NSPCs and how NSPCs can promote the formation of new blood vessels. This could lead to new insights into treatments for neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or injuries who are 21 years or older.
Not a fit: Patients with conditions unrelated to neurological function or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain repair mechanisms and lead to improved therapies for neurological injuries and diseases.
How similar studies have performed: Previous research has shown promising results in understanding cell interactions in similar contexts, suggesting potential for success in this novel approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Flanagan, Lisa a — University of California-Irvine
- Study coordinator: Flanagan, Lisa a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.