Interactions between bacteria and fungi in Crohn's Disease
Polymicrobial interactions in Crohn's Disease
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10652329
This study is looking at how certain fungi and bacteria in the gut might work together in people with Crohn's Disease, to see if these tiny organisms could affect how severe the disease is and how well treatments work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10652329 on ClinicalTrials.gov |
What this research studies
This research investigates the role of gut fungi and their interactions with bacteria in patients with Crohn's Disease. It focuses on how specific fungi, like Candida tropicalis, and bacteria, such as Escherichia coli and Serratia marcescens, work together to form biofilms that may contribute to the disease. By comparing the gut microbiomes of Crohn's patients to healthy individuals, the study aims to uncover significant differences in microbial communities that could influence disease severity and treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's Disease, particularly those experiencing severe symptoms or complications.
Not a fit: Patients without a diagnosis of Crohn's Disease or those with other gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting microbial interactions to improve treatment for Crohn's Disease.
How similar studies have performed: Previous research has shown promising results in understanding microbial interactions in other gastrointestinal diseases, suggesting potential for success in this area as well.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GHANNOUM, MAHMOUD A — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: GHANNOUM, MAHMOUD A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.