Intensive at-home arm rehabilitation after stroke
Official title: Telerehabilitation In The Home After Stroke: A Randomized, Controlled, Assessor-Blind Clinical Trial (The TR-2 Trial)
Funded at University of California Los Angeles · NIH-11204775 · Data updated 2026-11-12
People about four months after a stroke are offered a six-week daily telehealth program to improve arm movement and everyday functioning compared with usual care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $4,453,239 |
| NIH project number | 4UH3NS133283-02 |
| Project ID | NIH-11204775 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults about four months post-stroke who have substantial arm motor deficits but can participate in telehealth sessions from home.
✕Less likely to help
People with minimal arm impairment, those unable to use telehealth at home, or with medical or cognitive issues that prevent participation are unlikely to benefit.
What this research studies
This randomized, assessor-blind phase III trial will enroll about 202 people who have substantial arm weakness around four months after stroke. Participants are randomly assigned to either a six-week course of daily intensive arm motor therapy delivered at home by telehealth or to continue usual care. Therapists will guide exercises and monitor progress remotely, while blinded assessors measure arm function with the Action Research Arm Test and overall disability with the modified Rankin Scale. The study will also explore whether a brain imaging biomarker can help predict who benefits most.
Why it matters
Potential benefit: If successful, this could make intensive, effective arm rehabilitation available at home and improve arm function and independence for many stroke survivors.
How similar studies have gone: A recent StrokeNet trial showed that a similar six-week, home-based telerehabilitation program improved arm and global function comparable to in-clinic therapy, but this trial is the first large phase III comparison against usual care.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Cramer, Steven C. — University of California Los Angeles
- Study coordinator: Cramer, Steven C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.