Integrative data science for Alzheimer's
Core B: Integrative Data-Science Core
This project combines human brain samples and mouse models with advanced data science to find molecular changes linked to Alzheimer's disease that could guide future tests and treatments for people with Alzheimer's.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11166566 on NIH RePORTER |
What this research studies
Researchers will bring together high-resolution data from human samples and multiple mouse models and make sure experiments are done in the same way so results can be compared. They will use machine learning, deep learning, and network models to connect single-cell gene activity with other brain measures and disease features. The team will build data-tracking and sharing tools so results can be explored across the program in near real time. Much of the work is computational and supports many related projects that study the biology behind Alzheimer’s.
Who could benefit from this research
Good fit: People living with Alzheimer's disease or individuals willing to donate clinical data, blood, or brain tissue to research would be most relevant to the samples and data used here.
Not a fit: Patients without Alzheimer's or those seeking immediate treatment are unlikely to receive direct clinical benefit from this data-focused program in the short term.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets and better biomarkers that help diagnose Alzheimer's earlier or lead to more effective treatments.
How similar studies have performed: Prior multi-omics and machine-learning efforts have produced promising biomarkers and insights, but combining single-cell human maps with multimodal data across human and mouse models at this scale remains relatively novel.
Where this research is happening
San Francisco, United States
- J. David Gladstone Institutes — San Francisco, United States (Active)
Researchers
- Principal investigator: Pollard, Katherine S. — J. David Gladstone Institutes
- Study coordinator: Pollard, Katherine S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.