Integrating tumor DNA, RNA, and immune data to learn more about cancer
Comprehensive Analysis and Multi-Omics Data Integration for Cancer-Related Studies
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-11194357
This project builds computer tools that combine different kinds of tumor data to help researchers and doctors better understand cancers and how treatments like immunotherapy change tumors.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11194357 on ClinicalTrials.gov |
What this research studies
This effort develops bioinformatics pipelines and software to merge multiple kinds of tumor data—like DNA methylation, gene expression, T-cell receptor sequencing, and spatial assays—into unified analyses. The team works with cancer researchers across Johns Hopkins and with large datasets such as TCGA to analyze patient tumor samples and treatment-related changes in the tumor microenvironment. By standardizing high-throughput and spatial data analysis, the project aims to make it easier to spot patterns and biomarkers linked to response or resistance to therapies. The tools and analyses are shared with investigators to support broader cancer research and potential clinical follow-up.
Who could benefit from this research
Good fit: Patients with cancer who provide tumor samples or who take part in genomics-focused studies at Johns Hopkins or collaborating projects would be the most directly involved.
Not a fit: People who do not provide samples, whose cancers are not represented in the analyzed datasets, or who never interact with the participating centers are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help identify biomarkers and patterns that guide treatment choices and improve responses to cancer therapies like immunotherapy.
How similar studies have performed: Previous multi-omics and TCGA-based analyses have already revealed useful biomarkers and immune signatures, so this work builds on established and productive methods.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DANILOVA, LUDMILA — JOHNS HOPKINS UNIVERSITY
- Study coordinator: DANILOVA, LUDMILA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Center, Cancers, Comprehensive Cancer Center