Integrated molecular analysis for childhood acute myeloid leukemia
Integrated Systems Biology of Pediatric AML
This project combines DNA, methylation, and gene-activity data to find molecular markers that could help guide treatment for children with acute myeloid leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11241961 on NIH RePORTER |
What this research studies
This research will look at the DNA, methylation patterns, and gene activity in tumor samples from children with AML and combine those data to find patterns linked to outcomes. The team will use patient tumor samples and clinical information and apply an advanced statistical method (CC-PROMISE) to increase the chances of finding meaningful markers in a rare disease. Results may point to specific molecular features, such as DNMT3B-related changes, that could help match patients to therapies already being tested, including demethylating drugs.
Who could benefit from this research
Good fit: Children and adolescents under age 21 diagnosed with acute myeloid leukemia whose tumor samples and clinical data can be shared with the research team are the ideal candidates.
Not a fit: Adults with AML, patients without available tumor samples, or people with other blood cancers are unlikely to be included or to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could identify molecular markers to personalize treatment and improve outcomes for children with AML.
How similar studies have performed: Previous integrated genomic and methylation analyses in pediatric AML have revealed markers like DNMT3B linked to prognosis, so this approach builds on promising prior findings rather than being entirely experimental.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Lamba, Jatinder K. — University of Florida
- Study coordinator: Lamba, Jatinder K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.