Insulin's role in aging and metabolic diseases
Insulin regulates aging-associated genes through chromatin topology
This study is looking at how insulin affects genes related to aging and conditions like type 2 diabetes, using animal models to see how a specific protein called Tmtc2 helps manage calcium levels and influences aging, with the hope of finding new ways to treat age-related metabolic issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10973419 on NIH RePORTER |
What this research studies
This research investigates how insulin signaling affects genes associated with aging and metabolic diseases like type 2 diabetes. It aims to understand the mechanisms by which insulin regulates cellular responses to stress and aging through changes in chromatin structure. The study will utilize animal models to explore the role of a specific protein, Tmtc2, in calcium homeostasis and its impact on aging-related gene expression. By examining these processes, the research seeks to uncover potential therapeutic targets for age-related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related metabolic conditions, particularly those with type 2 diabetes.
Not a fit: Patients who are not experiencing metabolic disorders or are younger individuals without age-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that delay aging and improve metabolic health in patients.
How similar studies have performed: Previous research has shown promising results in understanding insulin's role in aging and metabolic diseases, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: Liu, Xiangyu — Joslin Diabetes Center
- Study coordinator: Liu, Xiangyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.